OriginalArticle
Age-relatedmagneticsusceptibilitychangesindeepgreymatterandcerebralcortexofnormalyoungandmiddle-agedadultsdepictedbywholebrainanalysisRomanaBurgetova1,2,PetrDusek1,3,AndreaBurgetova1^,AdamPudlac1,ManuelaVaneckova1,DanaHorakova3,JanKrasensky1,ZsokaVarga3,LukasLambert1
1DepartmentofRadiology,FirstFacultyofMedicine,CharlesUniversityandGeneralUniversityHospitalinPrague,Prague,CzechRepublic;2DepartmentofRadiology,ThirdFacultyofMedicine,CharlesUniversityandUniversityHospitalKrálovskéVinohrady,Prague,CzechRepublic;3DepartmentofNeurology,FirstFacultyofMedicine,CharlesUniversityandGeneralUniversityHospitalinPrague,Prague,CzechRepublic
Contributions:(I)Conceptionanddesign:PDusek,ABurgetova,LLambert;(II)Administrativesupport:ABurgetova,LLambert,APudlac;(III)Provisionofstudymaterialsorpatients:DHorakova,ZVarga,PDusek,MVaneckova,JKrasensky;(IV)Collectionandassemblyofdata:RBurgetova,MVaneckova,PDusek,JKrasensky,DHorakova;(V)Dataanalysisandinterpretation:PDusek,LLambert,RBurgetova,ABurgetova;(VI)Manuscriptwriting:Allauthors;(VII)Finalapprovalofmanuscript:Allauthors.
^ORCID:---.
Correspondenceto:Assoc.prof.AndreaBurgetova,MD,PhD.FirstFacultyofMedicineCharlesUniversityandGeneralFacultyHospitalinPrague,Unemocnice2,Prague2,CzechRepublic.Email:andrea.burgetova
vfn.cz.Background:Ironaccumulatesinbraintissueinhealthysubjectsduringaging.Ourgoalwastoconductadetailedanalysisofirondepositionpatternsinthecerebraldeepgreymatterandcortexusingregion-basedandwhole-brainanalysesofbrainmagneticsusceptibility.
Methods:BrainMRIwasperformedin95healthyindividualsagedbetween21and58yearsona3Tscanner.MRIprotocolincludedT1-weighted(T1W)magnetization-preparedrapidacquisitionwithgradientechoimagesand3Dflow-