QIMS之窗全脑分析显示正 [复制链接]

OriginalArticle

RomanaBurgetova1,2,PetrDusek1,3,AndreaBurgetova1^,AdamPudlac1,ManuelaVaneckova1,DanaHorakova3,JanKrasensky1,ZsokaVarga3,LukasLambert1

1DepartmentofRadiology,FirstFacultyofMedicine,CharlesUniversityandGeneralUniversityHospitalinPrague,Prague,CzechRepublic;2DepartmentofRadiology,ThirdFacultyofMedicine,CharlesUniversityandUniversityHospitalKrálovskéVinohrady,Prague,CzechRepublic;3DepartmentofNeurology,FirstFacultyofMedicine,CharlesUniversityandGeneralUniversityHospitalinPrague,Prague,CzechRepublic

ContributionsI)ConceptionanddesignDusek,ABurgetova,LLambert;(II)Administrativesupport:ABurgetova,LLambert,APudlac;(III)ProvisionofstudymaterialsorpatientsHorakova,ZVarga,PDusek,MVaneckova,JKrasensky;(IV)Collectionandassemblyofdata:RBurgetova,MVaneckova,PDusek,JKrasensky,DHorakova;(V)DataanalysisandinterpretationDusek,LLambert,RBurgetova,ABurgetova;(VI)Manuscriptwriting:Allauthors;(VII)Finalapprovalofmanuscript:Allauthors.

^ORCID:---.

Correspondenceto:Assoc.prof.AndreaBurgetova,MD,PhD.FirstFacultyofMedicineCharlesUniversityandGeneralFacultyHospitalinPrague,Unemocnice2,Prague2,CzechRepublic.Email:andrea.burgetova

Background:Ironaccumulatesinbraintissueinhealthysubjectsduringaging.Ourgoalwastoconductadetailedanalysisofirondepositionpatternsinthecerebraldeepgreymatterandcortexusingregion-basedandwhole-brainanalysesofbrainmagneticsusceptibility.

Methods:BrainMRIwasperformedin95healthyindividualsagedbetween21and58yearsona3Tscanner.MRIprotocolincludedT1-weighted(T1W)magnetization-preparedrapidacquisitionwithgradientechoimagesand3Dflow-